Propionyl chloride → HCID 21248376, compound

HRID 620022Notes

Reaction equation

HRID 620022 reaction equation
[OH:1][CH2:2][CH2:3][NH:4][C:5]1[CH:10]=[C:9]([CH3:11])[N:8]=[C:7]2[CH:12]=[N:13][NH:14][C:6]=12.[C:15](Cl)(=[O:18])[CH2:16][CH3:17]>>[C:15]([O:1][CH2:2][CH2:3][NH:4][C:5]1[CH:10]=[C:9]([CH3:11])[N:8]=[C:7]2[CH:12]=[N:13][NH:14][C:6]=12)(=[O:18])[CH2:16][CH3:17]

Participants

3

Reactant 2

HCID 62324Propionyl chlorideHCID 13747168HCID 13747168, compound

Product 1

HCID 21248376HCID 21248376, compound

Procedure

The title compound was prepared from 7-(2-hydroxyethylamino)-5-methyl-1H-pyrazolo[4,3-b]pyridine (2 g) and propionyl chloride by the method of Example 4. After purification by column chromatography on basic alumina with ethyl acetate and then a rising percentage of methanol as eluant the title compound was obtained as a white solid (1.7 g, 66%), m.p. 187°-190° C.

Workup

  1. customAfter purification by column chromatography on basic alumina with ethyl acetate

Sources & evidence

ORD record
ord-d69b08f32bd540849ddebc0b6b867b95
Source dataset
uspto-grants-1989_04
Patent number
US04818754

Reaction notes

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