Valeryl chloride → HCID 21248373, compound

HRID 620023Notes

Reaction equation

HRID 620023 reaction equation
[OH:1][CH2:2][CH2:3][NH:4][C:5]1[C:6]2[C:7](=[CH:12][N:13]([CH3:15])[N:14]=2)[N:8]=[C:9]([CH3:11])[CH:10]=1.[C:16](Cl)(=[O:21])[CH2:17][CH2:18][CH2:19][CH3:20]>>[C:16]([O:1][CH2:2][CH2:3][NH:4][C:5]1[C:6]2[C:7](=[CH:12][N:13]([CH3:15])[N:14]=2)[N:8]=[C:9]([CH3:11])[CH:10]=1)(=[O:21])[CH2:17][CH2:18][CH2:19][CH3:20]

Participants

3

Reactant 2

HCID 61186Valeryl chlorideHCID 21248381HCID 21248381, compound

Product 1

HCID 21248373HCID 21248373, compoundYield 74%

Procedure

The title compound was prepared from 7-(2-hydroxyethylamino)-2,5-dimethylpyrazolo[4,3-b]pyridine (D2) (400 mg) and valeryl chloride by the general method of Example 4. The solid obtained was recrystallized from ether/methanol to give the title compound (300 mg, 74%), m.p. 78°-80° C.

Workup

  1. customThe solid obtained
  2. customwas recrystallized from ether/methanol

Sources & evidence

ORD record
ord-1e3a2f53beae4cdb93ab47eb6fe1137f
Source dataset
uspto-grants-1989_04
Patent number
US04818754

Reaction notes

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