Chloroacetic Acid → 115835-43-3

HRID 620034Notes

Reaction equation

HRID 620034 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([NH:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[NH2:15])[CH:5]=[CH:6][CH:7]=1.[Cl:16][CH2:17][C:18](O)=O.C(=O)([O-])[O-].[Na+].[Na+]>O>[F:1][C:2]1[CH:3]=[C:4]([N:8]2[C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[N:15]=[C:18]2[CH2:17][Cl:16])[CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 300Chloroacetic AcidHCID 10340Sodium CarbonateHCID 21248421HCID 21248421, compound

Product 1

HCID 21248416115835-43-3

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
130 °C

Procedure

A mixture of N-(3-fluorophenyl)-o-phenylenediamine (0.8 g, 4 mmol) prepared in the preceding step (a), polyphosphoric ester (2.7 g) and monochloroacetic acid (0.4 g, 4.2 mmol) was heated for 1 hour at 130° C. and water was added to the reaction mixture to decompose an excess of polyphosphoric ester, then neutralized with sodium carbonate and the occurred oily substance was extracted with chloroform and the extract was washed, dried and concentrated in vacuo.

Workup

  1. extractionthe occurred oily substance was extracted with chloroform
  2. washthe extract was washed
  3. customdried
  4. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-c8562ea73a6143e88762b9fffa07ae2d
Source dataset
uspto-grants-1989_04
Patent number
US04818761

Reaction notes

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