Chloroacetic Acid → HCID 14456400, compound

HRID 620036Notes

Reaction equation

HRID 620036 reaction equation
[NH:1]([C:8]1[CH:14]=[C:13]([CH2:15][CH3:16])[C:12]([Cl:17])=[CH:11][C:9]=1[NH2:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:18][CH2:19][C:20](O)=O.C(=O)([O-])[O-].[Na+].[Na+]>O>[C:2]1([N:1]2[C:8]3[CH:14]=[C:13]([CH2:15][CH3:16])[C:12]([Cl:17])=[CH:11][C:9]=3[N:10]=[C:20]2[CH2:19][Cl:18])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 300Chloroacetic AcidHCID 10340Sodium CarbonateHCID 14456399HCID 14456399, compound

Product 1

HCID 14456400HCID 14456400, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
130 °C

Procedure

A mixture of 2-anilino-4-ethyl-5-chloroaniline (3.3 g, 13.4 mmol) prepared in the preceding step (a), polyphosphoric ester (8.9 g) and monochloroacetic acid (1.3 g, 13.4 mmol) was heated for 1 hour at 130° C. under stirring. Water was added to the reaction mixture to decompose an excess of the ester and they were neutralized with sodium carbonate and the occurred oily substance was extracted with chloroform, which was washed, dried, and concentrated in vacuo.

Workup

  1. extractionthe occurred oily substance was extracted with chloroform, which
  2. washwas washed
  3. customdried
  4. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-cb7bae1e1b8e47a5bbeb2e573bcf914f
Source dataset
uspto-grants-1989_04
Patent number
US04818761

Reaction notes

Loading…