Potassium Hydroxide → HCID 12674277, compound

HRID 620051Notes

Reaction equation

HRID 620051 reaction equation
[C:1]1([C:7]2[CH:8]=[N:9][C:10]([N:13]3[CH2:18][CH2:17][N:16](C(OCC)=O)[CH2:15][CH2:14]3)=[N:11][CH:12]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[K+]>C(O)C.O>[C:1]1([C:7]2[CH:12]=[N:11][C:10]([N:13]3[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]3)=[N:9][CH:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

5

Reactant 2

HCID 14797Potassium HydroxideHCID 3631156HCID 3631156, compound

Product 1

HCID 12674277HCID 12674277, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

0.04 mol of ethyl 1-(5-phenyl-2-pyrimidinyl)-4-piperazinecarboxylate are boiled under reflux with 0.78 mol of KOH in 400 ml of C2H5OH and 40 ml of H2O under N2 protective gas for 15 hours. The mixture is evaporated to dryness, water is added and the residue is taken up in CH2Cl2. After washing with water, the organic phase is separated off and evaporated to dryness, whereupon the amine is obtained as crystals.

Workup

  1. customThe mixture is evaporated to dryness, water
  2. additionis added
  3. washAfter washing with water
  4. customthe organic phase is separated off
  5. customevaporated to dryness, whereupon the amine
  6. customis obtained as crystals

Sources & evidence

ORD record
ord-daf88af102b34271a7156f2a73acb769
Source dataset
uspto-grants-1989_04
Patent number
US04818756

Reaction notes

Loading…