HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 620059Generated: October 25, 2026
1,3-Dibromopropane → 2-(3-bromopropyl)-7-methoxy-1,2,4-benzothiadiazin-3(4H)one 1,1-dioxide
https://huagongshe.com/reaction/620059
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1,3-Dibromopropane | HCID 8001 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | 7-Methoxy-2H-benzo[e][1,2,4]thiadiazin-3(4H)-one 1,1-dioxide | HCID 12528490 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-(3-bromopropyl)-7-methoxy-1,2,4-benzothiadiazin-3(4H)one 1,1-dioxide | HCID 19023431 | — |
Reaction Steps
0.03 mol of 7-methoxy-1,2,4-benzothiadiazin-3(4H)one 1,1-dioxide is dissolved in 50 ml of absolute DMF, and 0.03 mol of sodium hydride is added. After 15 minutes, formation of the sodium salt was complete. The 0.06 mol of 1,3-dibromopropane is added dropwise and the mixture is heated at 80° C. for 2 hours. The solvent is then distilled out and the residue is purified by column chromatography on silica gel. The eluting agent used was a mixture of CH2Cl2 /CH3OH (98:2).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04818756 |
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| Source dataset | uspto-grants-1989_04 |
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| ORD ID | ord-2897115ebd4d4550a586a68ea4b6662a |
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| Source note | uspto-grants-1989_04 |
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