HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 62008Generated: October 29, 2026
Hydrochloric Acid → 5-[3,4-Bis(benzyloxy)-5-nitrophenyl]-2H-tetrazole
https://huagongshe.com/reaction/62008
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | Sodium Azide | HCID 33557 | — |
| Reactant | 3,4-Bis(benzyloxy)-5-nitrobenzonitrile | HCID 67036994 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 5-[3,4-Bis(benzyloxy)-5-nitrophenyl]-2H-tetrazole | HCID 67037054 | — |
Reaction Steps
A mixture of 3,4-bis-benzyloxy-5-nitro-benzonitrile (0.54 g, 1.50 mmol), sodium azide (0.15 g, 2.25 mmol) and ammonium chloride (0.12 g, 2.25 mmol) in dimethylformamide (3 mL) was stirred at 85° C. for 20 hours. After cooling to room temperature, the reaction mixture was poured onto water (30 mL) and acidified with dilute hydrochloric acid. The resulting precipitate was collected, washed with water and dried to yield 5-(3,4-bis-benzyloxy-5-nitrophenyl)-2H-tetrazole, 0.53 g (87%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09446012B2 |
|---|
| Source dataset | uspto-grants-2016_09 |
|---|
| ORD ID | ord-e6af85c9b6ec47b3b044a76fc1298ea1 |
|---|
| Source note | uspto-grants-2016_09 |
|---|
