2-(Oxiran-2-ylmethoxy)benzonitrile → HCID 70393792, compound

Participants

Reaction Steps

A solution of 3.5 g (6.8 mmol) of 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-pyridine-3,5-dicarboxylic acid 3-{2-[p-(2-aminoethoxy)-phenoxy]-ethyl}-ester 5-methyl ester and 1.55 g (8.9 mmol) of 2-(2,3-epoxypropoxy)-benzonitrile in 20 ml of isopropanol is heated under reflux for 2 hours. The oil obtained after concentration by evaporation (approximately 6 g) is purified by "flash" chromatography analogously to Example 1 and yields 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-pyridine-3,5-dicarboxylic acid 3-{{{2-{{p-{2-[3-(o-cyanophenoxy)-2-hydroxypropylamino]-ethoxy}-phenoxy}}-ethyl}}}-ester 5-methyl ester in the form of an amorphous solid.

Provenance & Evidence