Potassium Carbonate → HCID 70393619, compound

Participants

Reaction Steps

8.7 g (24 mmol) of the bromine derivative obtained in step 2b), 8.0 g (24 mmol) of 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridine-dicarboxylic acid monomethyl ester and 6.6 g (48 mmol) of potassium carbonate are heated at boiling in 100 ml of acetonitrile for 20 hours while stirring and under reflux. Working up analogously to Example 1c yields 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-pyridine-3,5-dicarboxylic acid 3-{2-[p-(2-tertiary butoxycarbonylaminoethoxy)-phenoxy]-ethyl}-ester 5-methyl ester, which is used in the following step without being purified further.

Provenance & Evidence