HCID 70393619, compound → HCID 70393778, compound

HRID 620084Notes

Reaction equation

HRID 620084 reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:6]([C:36]2[CH:41]=[CH:40][CH:39]=[C:38]([N+:42]([O-:44])=[O:43])[CH:37]=2)[C:7]([C:13]([O:15][CH2:16][CH2:17][O:18][C:19]2[CH:24]=[CH:23][C:22]([O:25][CH2:26][CH2:27][NH:28]C(OC(C)(C)C)=O)=[CH:21][CH:20]=2)=[O:14])=[C:8]([CH3:12])[NH:9][C:10]=1[CH3:11])=[O:4]>C(O)=O>[CH3:1][O:2][C:3]([C:5]1[CH:6]([C:36]2[CH:41]=[CH:40][CH:39]=[C:38]([N+:42]([O-:44])=[O:43])[CH:37]=2)[C:7]([C:13]([O:15][CH2:16][CH2:17][O:18][C:19]2[CH:24]=[CH:23][C:22]([O:25][CH2:26][CH2:27][NH2:28])=[CH:21][CH:20]=2)=[O:14])=[C:8]([CH3:12])[NH:9][C:10]=1[CH3:11])=[O:4]

Participants

3

Reactant 1

HCID 70393619HCID 70393619, compound

Product 1

HCID 70393778HCID 70393778, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

14.6 g of the product obtained in step (2c) are dissolved in 50 ml of formic acid. The solution is allowed to stand for 6 hours at room temperature and is worked up analogously to Example (1d). A crystalline crude product is thus obtained, which, after recrystallisation from acetonitrile, yields 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-pyridine-3,5-dicarboxylic acid 3-{2-[p-(2-aminoethoxy)-phenoxy]-ethyl}-ester 5-methyl ester, which has a melting point of 153°-154°.

Workup

  1. customA crystalline crude product is thus obtained
  2. customwhich, after recrystallisation from acetonitrile

Sources & evidence

ORD record
ord-622228ba4301454b857493c2fdf990d0
Source dataset
uspto-grants-1989_04
Patent number
US04818766

Reaction notes

Loading…