2-(Oxiran-2-ylmethoxy)benzonitrile → 1,4-Dihydro-2,6-dimethyl-4-(m-nitrophenyl)-pyridine-3,5-dicarboxylic acid 3-{{{2-{{p-{2-[3-(o-cyanophenoxy)-2-hydroxypropylamino]-2-methylpropoxy}-phenoxy}}-ethyl}}}-ester 5-methyl ester

Participants

Reaction Steps

A solution of 5.4 g (10 mmol) of 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-pyridine-3,5-dicarboxylic acid 3-{2-[p-(2-amino-2-methylpropoxy)-phenoxy]-ethyl}-ester 5-methyl ester and 2.3 g (13 mmol) of 2-(2,3-epoxypropoxy)-benzonitrile in 30 ml of isopropanol is heated under reflux for 18 hours. After working up and chromatography analogously to Example 1, 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-pyridine-3,5-dicarboxylic acid 3-{{{2-{{p-{2-[3-(o-cyanophenoxy)-2-hydroxypropylamino]-2-methylpropoxy}-phenoxy}}-ethyl}}}-ester 5-methyl ester is obtained in the form of an amorphous solid.

Provenance & Evidence