HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Dibromoethane → 1-(2-Bromoethoxy)-4-[2-(tertiary butoxycarbonylamino)-2-methylpropoxy]-benzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Dibromoethane | HCID 7839 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | p-[2-(Tertiary butoxycarbonylamino)-2-methylpropoxy]-phenol | HCID 54328448 | — |
| Catalyst | Benzyl triethylammonium chloride | HCID 66133 | — |
| Product | 1-(2-Bromoethoxy)-4-[2-(tertiary butoxycarbonylamino)-2-methylpropoxy]-benzene | HCID 21248438 | — |
Reaction Steps
Analogously to Example (2b), a mixture of 19.2 g (68 mmol) of p-[2-(tertiary butoxycarbonylamino)-2-methylpropoxy]-phenol, 47 g (340 mmol) of potassium carbonate and 1.5 g of triethylbenzylammonium chloride is reacted in 57 ml (680 mmol) of 1,2-dibromoethane and worked up. Crude 1-(2-bromoethoxy)-4-[2-(tertiary butoxycarbonylamino)-2-methylpropoxy]-benzene is obtained in the form of an oil, which is used further in crude form.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04818766 |
| Source dataset | uspto-grants-1989_04 |
| ORD ID | ord-74502b05368e48e2914891a1fe07cd7d |
| Source note | uspto-grants-1989_04 |