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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 620125Generated: October 30, 2026

Hippuric Acid → Azlactone

https://huagongshe.com/reaction/620125

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHippuric AcidHCID 464—
SolventAcetic AnhydrideHCID 7918—
ProductAzlactoneHCID 65073—

Reaction Conditions

Temperature60 °C

Reaction Steps

Into 270 ml of acetic acid anhydride, 89.5 g (0.5M) of hippuric acid was added, and the thus obtained mixture was stirred for 1.5 hours at 60° C. to obtain a uniform solution of 2-phenyl-2-oxazolin-5-one, which was preserved by cooling to -20° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04820334
Source datasetuspto-grants-1989_04
ORD IDord-a377e242ccd64059a6043801a51cd2db
Source noteuspto-grants-1989_04