反应详情

To a stirred suspension of 3,4-dimethoxy-N-methyl-5-nitro-benzamide (0.40 g, 1.66 mmol) in toluene (10 mL) was added phosphorous pentachloride (0.28 g, 1.83 mmol) portionwise. Upon completion of addition, the reaction mixture was warmed to reflux till complete disappearance of starting material. Evaporation to dryness resulted in a crude solid that was washed with diethyl ether, affording 3,4-dimethoxy-N-methyl-5-nitro-benzimidoyl chloride, 0.37 g (85%).

1. additionUpon completion of addition
2. temperaturethe reaction mixture was warmed
3. temperatureto reflux till complete disappearance of starting material
4. customEvaporation to dryness
5. customresulted in a crude solid
6. washthat was washed with diethyl ether