HuagongsheHuagongshe Chemistry Print Report · For research reference only
Enprofylline → 3-Propyl-6-thioxanthine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Enprofylline | HCID 1676 | — |
| Reactant | Phosphorus sulfide (P2S5) | HCID 14817 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 3-Propyl-6-thioxanthine | HCID 14014540 | — |
Reaction Steps
A suspension of 9.32 g. (48 mM) of 3-propylxanthine in 80 ml. of pyridine, was treated with 17.33 g. (78 mM.) of phosphorus pentasulfide in 80 ml. of pyridine, and worked up analogously to Example I. 8.9 g. of 3-propyl-6-thioxanthine was obtained. Recyrstallization from methanol-acetone gave 7.4 g. (59% yield) of needles with a melting point of 249°-250° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04820709 |
| Source dataset | uspto-grants-1989_04 |
| ORD ID | ord-9f94ce3856e44840b57ffdc15b1a7150 |
| Source note | uspto-grants-1989_04 |