huagongshe.com
HRID620149

反应详情

EQUATION

反应方程式

HRID 620149 的结构方程式

REACTANTS

反应物

3
结构：[BH4-].[Li+]
HCID4148881

Lithium borohydride

BH4Li

结构：CC[C@H](C)[C@H](NC(=O)OC(C)(C)C)C(=O)OC
HCID11791441

Boc-L-isoleucine methyl ester

C12H23NO4

结构：CO.ClC(Cl)Cl
HCID21584188

Chloroform methanol

C2H5Cl3O

PRODUCTS

生成物

1
结构：CC[C@H](C)[C@@H](CO)NC(=O)OC(C)(C)C
HCID14237729

tert-Butyl [(2S,3S)-1-hydroxy-3-methylpentan-2-yl]carbamate

C11H23NO3

收率 97%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：COCCOC
溶剂HCID8071

未命名化合物

PROCEDURE

实验过程

This compound was prepared in 97% yield from the ester 4c (9.84 g, 40 mmol) by reduction with lithium borohydride in dry DME analogous to the method described earlier1,2. TLC Rf 0.47 (eluent MeOH/CHCl3, 7/93). 1H NMR (CDCl3) δ 0.83-1.03 (m, 6H, CHCH3, CH2CH3), 1.03-1.40 (m, 2H, CH2CH3, CH2CH3), 1.44 (s, 9H, t-Bu), 2.21-2.61 (m, 1H, CHCH3), 3.32-3.88 (m, 4H, CHCH2OH), 4.52-4.68 (m, 1H, NH), CI MS, m/e 218 (M+ +1).