HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 62015Generated: October 29, 2026
Hydrochloric Acid → 3-(2H-tetrazol-5-yl)-2-(trifluoromethyl)pyridine
https://huagongshe.com/reaction/62015
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | Sodium Azide | HCID 33557 | — |
| Reactant | 2-(Trifluoromethyl)pyridine-3-carbonitrile | HCID 26986387 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 3-(2H-tetrazol-5-yl)-2-(trifluoromethyl)pyridine | HCID 68704491 | — |
Reaction Steps
A mixture of 2-(trifluoromethyl)nicotinonitrile (0.43 g, 2.50 mmol), sodium azide (0.24 g, 3.75 mmol), and ammonium chloride (0.20 g, 3.75 mmol) in dimethylformamide (2.5 mL) was stirred at 85° C. for 20 hours. After cooling to room temperature, the reaction mixture was poured onto water (20 mL) and acidified with dilute hydrochloric acid. The resulting precipitate was collected, washed with water and dried to yield 3-(2H-tetrazol-5-yl)-2-(trifluoromethyl)pyridine, 0.484 g (90%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09446012B2 |
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| Source dataset | uspto-grants-2016_09 |
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| ORD ID | ord-7bdffca34e2d4750a24299441ea112f8 |
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| Source note | uspto-grants-2016_09 |
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