HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(Chloromethyl)-4-(piperidin-1-yl)pyrimidine → HCID 178488127, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(Chloromethyl)-4-(piperidin-1-yl)pyrimidine | HCID 14306133 | — |
| Reactant | HCID 178488032 | HCID 178488032 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Product | HCID 178488127 | HCID 178488127 | 72.1% |
Reaction Steps
A mixture of 2-chloromethyl-4-piperidinopyrimidine (2.89 g) and 2-mercapto-5-methoxybenzimidazole (2.46 g) in ethanol (40 ml) and lN sodium hydroxide (15 ml) was stirred at room temperature for 16 hours. After stripping the residue was washed with water and recrystallised from acetonitrile to give 5-methoxy-2-(4-piperidino-2-pyrimidinylmethylthio)-(1H)-benzimidazole (3.5 g) m.p. 145°-147°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04820708 |
| Source dataset | uspto-grants-1989_04 |
| ORD ID | ord-c57b2c3864d04b71895a08da403b1409 |
| Source note | uspto-grants-1989_04 |