HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → 4-(2-(Chloromethyl)pyrimidin-4-yl)morpholine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | [4-(Morpholin-4-yl)pyrimidin-2-yl]methanol | HCID 14306153 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 4-(2-(Chloromethyl)pyrimidin-4-yl)morpholine hydrochloride | HCID 22166902 | — |
Reaction Steps
Thionyl chloride (3.4 ml) was added dropwise to a stirred solution of 2-hydroxymethyl-4-morpholinopyrimidine in chloroform (30 ml) cooled in an ice bath. The mixture was allowed to warm to room temperature and left to stand for a further 1.5 hours. The solution was reduced to low volume, and ether added with stirring to give 2-chloromethyl-4-morpholinopyrimidine hydrochloride (3.8 g) as a crystalline solid, m.p. 214°-6°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04820708 |
| Source dataset | uspto-grants-1989_04 |
| ORD ID | ord-871bef018daf47bc95a92fd8040463e7 |
| Source note | uspto-grants-1989_04 |