Dimethylamine → HCID 21245795, compound

HRID 620162Notes

Reaction equation

HRID 620162 reaction equation
[CH3:1][NH:2][CH3:3].[CH3:4][O:5][CH2:6][C:7]1[N:12]=[C:11](Cl)[CH:10]=[CH:9][N:8]=1.O>C(O)C>[CH3:4][O:5][CH2:6][C:7]1[N:12]=[C:11]([N:2]([CH3:3])[CH3:1])[CH:10]=[CH:9][N:8]=1

Participants

5

Reactant 3

HCID 674DimethylamineHCID 962WaterHCID 14306130105950-89-8

Product 1

HCID 21245795HCID 21245795, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

A 33% w/w solution of dimethylamine in ethanol (45 ml) was added dropwise to a stirred solution of 2-methoxymethyl-4-chloropyrimidine (7.54 g) in ethanol (100 ml), cooled over an ice bath. The mixture was allowed to warm to room temperature, and left to stand for 16 hours. After stripping, the residue was treated with water (100 ml), and extracted with chloroform. The extracts were dried (K2CO3) and stripped to give 2-methoxymethyl-4-dimethylaminopyrimidine (7.41 g) as an oil.

Workup

  1. temperaturecooled over an ice bath
  2. waitleft
  3. extractionextracted with chloroform
  4. dry with materialThe extracts were dried (K2CO3)

Sources & evidence

ORD record
ord-77cc6b6681604ee5905af291a16a4066
Source dataset
uspto-grants-1989_04
Patent number
US04820708

Reaction notes

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