化工社化工社 化学情報印刷レポート · 研究参考用
Ammonia → HCID 178488165、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | m-Chloroperbenzoic acid | HCID 70297 | — |
| 反応物 | HCID 178488135 | HCID 178488135 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | HCID 178488165 | HCID 178488165 | 63.7% |
反応手順
A solution of m-chloroperbenzoic acid (2.16 g) in dichloromethane (40 ml) was added to a stirred solution of 5-methoxy-2-(5-methyl-6-piperidino-4-pyrimidinylmethylthio)-(1H)-benzimidazole (4.0 g) in dichloromethane (110 ml) cooled to between -40° and -50°. After a further hour at -40°, ammonia was passed through the reaction mixture and the precipitated solid filtered off. The filtrate was stripped, and the residual glass triturated with acetonitrile to give 5-methoxy-2-(5-methyl-6-piperidino-4-pyrimidinylmethylsulphinyl)-(1H)-benzimidazole 2.66 g, m.p. 87°-89°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04820708 |
| 出典データセット | uspto-grants-1989_04 |
| ORD ID | ord-c295573e3d6d41ddad39e96c09d5a0f6 |
| 出典メモ | uspto-grants-1989_04 |