Lawesson's reagent → HCID 135503959, compound

Participants

Reaction Steps

A suspension of 9.8 g of 5-(2-chlorophenyl)-7-[2-(4-isobutylphenyl)ethyl]-1,3-dihydro-2H-thieno[2,3-e]-1,4-diazepin-2-one and 5.5 g of Lawesson reagent in 200 ml of toluene is stirred at 40°-43° C. for an hour. The resultant solution is concentrated under reduced pressure, and the residue is subjected to chromatography on silica gel and then eluted with chloroformmethanol (100:1 to 100:2). The objective fraction is concentrated under reduced pressure to give 9.6 g of 5-(2-chlorophenyl)-7-[2-(4-isobutylphenyl)ethyl]-1,3-dihydro-2H-thieno[2,3-e]-1,4-diazepine-2-thione, melting at 180°-182° C. with decomposition.

Provenance & Evidence