Lawesson's reagent → HCID 136113976, compound

Participants

Reaction Steps

A suspension of 8.9 g of 5-(2-chlorophenyl)-7-[4-(4-isobutylphenyl)butyl]-1,3-dihydro-2H-thieno[2,3-e]-1,4-diazepin-2-one, melting at 133°-135° C. and 4.7 g of Lawesson reagent in 100 ml of toluene is stirred at 38°-40° C. for an hour. The resultant solution is concentrated under reduced pressure, and the residue is subjected to chromatography on silica gel and then eluted with chloroform-methanol (100:1 to 100:2). The objective fraction is concentrated under reduced pressure to give 8 g of 5-(2-chlorophenyl)-7-[4-(4-isobutylphenyl)butyl]-1,3-dihydro-2H-thieno[2,3-e]-1,4-diazepine-2-thione, melting at 169°-171° C. with decomposition.

Provenance & Evidence