Lawesson's reagent → HCID 136062684, compound

Participants

Reaction Steps

A suspension of 7 g of 5-(2-chlorophenyl)-7-[2-(4-methoxyphenyl)ethyl]-1,3-dihydro-2H-thieno[2,3-e]-1,4-diazepin-2-one, melting at 196°-198° C. and 5 g of Lawesson reagent in 100 ml of toluene is stirred at 45°-48° C. for an hour. The resultant solution is concentrated under reduced pressure, and the residue is subjected to chromatography on silica gel and then eluted with chloroform-methanol (100:1 to 100:2). The objective fraction is concentrated under reduced pressure to give 7 g of 5-(2-chlorophenyl)-7-[2-(4-methoxyphenyl)ethyl]-1,3-dihydro-2H-thieno[2,3-e]-1,4-diazepine-2-thione, melting at 185°-186° C. with decomposition.

Provenance & Evidence