(+-)-Methionine → HCID 14424031, compound

Participants

Reaction Steps

A mixture of 1.5 g of thienotriazolodiazepine compound obtained in Example 4 and 5 g of DL-methionine in 100 ml of methanesulfonic acid is allowed to stand at room temperature for 24 hours. The mixture is poured into 300 ml of ice-water, neutrarized with an aqueous sodium hydrogencarbonate solution and extracted with ethyl acetate. The organic layer is washed with a saturated sodium chloride solution and dried over anhydrous magnesium sulfate. After separating by filtration, the filtrate is concentrated to precipitate colorless crystals. The crystals are collected by filtration, washed with isopropyl ether and dried to give 0.9 g of 4-(2-chlorophenyl)-2-[2-(4-hydroxyphenyl)ethyl]-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine, melting at 100°-100° C.

Provenance & Evidence