Isopropyl iodide → HCID 14424032, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 0.5 g of thienotriazolodiazepine compound obtained in Example 5, 0.2 g of potassium hydroxide and 0.62 g of isopropyl iodide in 20 ml of 2-methoxyethanol is stirred at 90° C. for 4 hours, and then the resulting mixture is concentrated to dryness. The residue is dissolved in 50 ml of chloroform, washed with water and dried over anhydrous magnesium sulfate. After separating by filtration, the filtrate is concentrated under reduced pressure and the residue is crystallized from isopropyl ether-ethyl acetate to give 0.3 g of 4-(2-chlorophenyl)-2-[2-(4-isopropoxyphenyl)ethyl]-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine as colorless crystals, melting at 121°-124° C.

Provenance & Evidence