Sodium Hydroxide → 4-[2-[(4-methylphenyl)sulfonylamino]-2,3-dihydro-1H-inden-5-yl]-4-oxobutanoic acid

HRID 620199Notes

Reaction equation

HRID 620199 reaction equation
[C:1]1([CH3:28])[CH:6]=[CH:5][C:4]([S:7]([NH:10][CH:11]2[CH2:19][C:18]3[C:13](=[CH:14][CH:15]=[C:16]([C:20](=[O:27])[CH2:21][CH2:22][C:23]([O:25]C)=[O:24])[CH:17]=3)[CH2:12]2)(=[O:9])=[O:8])=[CH:3][CH:2]=1.[OH-].[Na+]>>[C:1]1([CH3:28])[CH:2]=[CH:3][C:4]([S:7]([NH:10][CH:11]2[CH2:19][C:18]3[C:13](=[CH:14][CH:15]=[C:16]([C:20](=[O:27])[CH2:21][CH2:22][C:23]([OH:25])=[O:24])[CH:17]=3)[CH2:12]2)(=[O:9])=[O:8])=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 14071511Methyl 4-(2-p-toluenesulphonamido-indan-5-yl)-4-oxobutyrate

Product 1

HCID 140715124-[2-[(4-methylphenyl)sulfonylamino]-2,3-dihydro-1H-inden-5-yl]-4-oxobutanoic acid

Procedure

Preparated analogously to Example 2 from methyl 4-(2-p-toluenesulphonamido-indan-5-yl)-4-oxobutyrate by hydrolysis with sodium hydroxide.

Sources & evidence

ORD record
ord-da4ef245f9434f6e809ebfb4c782d1d7
Source dataset
uspto-grants-1989_04
Patent number
US04820705

Reaction notes

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