HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-{2-[(4-Chlorobenzene-1-sulfonyl)amino]-2,3-dihydro-1H-inden-5-yl}-4-oxobutanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Succinic anhydride | HCID 7922 | — |
| Reactant | HCID 3248380 | HCID 3248380 | — |
| Reactant | Aluminum(III) Chloride | HCID 6451240 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Product | 4-{2-[(4-Chlorobenzene-1-sulfonyl)amino]-2,3-dihydro-1H-inden-5-yl}-4-oxobutanoic acid | HCID 3087365 | — |
Reaction Steps
38.5 g (0.289 mol) of anhydrous aluminium chloride and 12.4 g (0.124 mol) of succinic anhydride are suspended in 250 ml of ethylene chloride and 25.4 g (0.082 mol) of 2-p-chlorobenzenesulphonamido-indane are then added, with vigorous stirring. In the course of this, a clear solution is formed. After 3 hours, the product is decomposed by means of ice and hydrochloric acid, and the reaction product is isolated from the organic phase. It is recrystallised from glacial acetic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04820705 |
| Source dataset | uspto-grants-1989_04 |
| ORD ID | ord-50107c2a2bc44d00bc19598a185ecb29 |
| Source note | uspto-grants-1989_04 |