Hydrazine → Benzenesulfonamide, N-(2,3-dihydro-5-(1,4,5,6-tetrahydro-6-oxo-3-pyridazinyl)-1H-inden-2-yl)-4-methoxy-

HRID 620206Notes

Reaction equation

HRID 620206 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([S:9]([NH:12][CH:13]2[CH2:21][C:20]3[C:15](=[CH:16][CH:17]=[C:18]([C:22](=O)[CH2:23][CH2:24][C:25]([O:27]C)=O)[CH:19]=3)[CH2:14]2)(=[O:11])=[O:10])=[CH:5][CH:4]=1.[NH2:30][NH2:31]>C(O)(=O)C>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([S:9]([NH:12][CH:13]2[CH2:21][C:20]3[C:15](=[CH:16][CH:17]=[C:18]([C:22]4[CH2:23][CH2:24][C:25](=[O:27])[NH:30][N:31]=4)[CH:19]=3)[CH2:14]2)(=[O:11])=[O:10])=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 9321HydrazineHCID 14071515Methyl 4-(2-p-methoxybenzenesulphonamido-indan-5-yl)-4-oxobutyrate

Product 1

HCID 3087368Benzenesulfonamide, N-(2,3-dihydro-5-(1,4,5,6-tetrahydro-6-oxo-3-pyridazinyl)-1H-inden-2-yl)-4-methoxy-

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

5.0 g (12 mmol) of methyl 4-(2-p-methoxybenzenesulphonamido-indan-5-yl)-4-oxobutyrate and 3.0 g (60 mmol) of 99% hydrazine in 25 ml of glacial acetic acid are boiled for 30 minutes. The mixture is evaporated, water is added to the residue, and the reaction product is filtered off with suction and recrystallised from n-propanol.

Workup

  1. customThe mixture is evaporated
  2. additionwater is added to the residue
  3. filtrationthe reaction product is filtered off with suction
  4. customrecrystallised from n-propanol

Sources & evidence

ORD record
ord-c46ac3bf53f14a998cb793dd56f138d1
Source dataset
uspto-grants-1989_04
Patent number
US04820705

Reaction notes

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