反应详情

600 mg (15 mmol) of sodium hydroxide in 2 ml of water are added to 2.3 g (5 mmol) of 4-carbethoxy-6-(2-p-toluenesulfonamido-indan-5-yl)-dihydro-pyridazin-3(2H)-one in 40 ml of ethanol, and the mixture is stirred over night in order to achieve hydrolysis. The reaction product which is precipitated on acidifying is filtered off with suction and heated in glacial acetic acid for 10 minutes at the boil. The desired compound crystallises out on cooling.

1. customhydrolysis
2. customThe reaction product which is precipitated on acidifying
3. filtrationis filtered off with suction
4. temperatureheated in glacial acetic acid for 10 minutes at the boil
5. customThe desired compound crystallises out
6. temperatureon cooling