HCID 15614980, compound → HCID 15615006, compound

HRID 620227Notes

Reaction equation

HRID 620227 reaction equation
C([NH:11][C@H:12]([C:14]([N:16]([C:21]1[CH:22]=[C:23]2[C:27](=[CH:28][CH:29]=1)[CH2:26][CH2:25][CH2:24]2)[CH2:17][C:18]([OH:20])=[O:19])=[O:15])[CH3:13])(OCC1C=CC=CC=1)=O>[Pd].C(O)C.O>[NH2:11][C@H:12]([C:14]([N:16]([C:21]1[CH:22]=[C:23]2[C:27](=[CH:28][CH:29]=1)[CH2:26][CH2:25][CH2:24]2)[CH2:17][C:18]([OH:20])=[O:19])=[O:15])[CH3:13]

Participants

5

Reactant 1

HCID 15614980HCID 15614980, compound

Product 1

HCID 15615006HCID 15615006, compound

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 702EthanolSolventHCID 962WaterSolvent

Procedure

A solution of N-carbobenzoxy-L-alanyl-N-(5-indanyl)glycine (4.5 g) and 10% palladium on carbon (1.0 g) in 250 ml ethanol was hydrogenated at 25 psi for 2 h and filtered. Concentration of the volatiles in vacuo provided a residue which was dissolved in H2O and filtered over Celite. Lyophilization of the filtrate provided the crystalline (m.p. 119°-120° C.) product.

Workup

  1. filtrationfiltered
  2. customConcentration of the volatiles in vacuo provided a residue which
  3. filtrationfiltered over Celite

Sources & evidence

ORD record
ord-6328fd137b55471d8480491258a7a061
Source dataset
uspto-grants-1989_04
Patent number
US04820729

Reaction notes

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