Dicyclohexylcarbodiimide → HCID 11784295, compound

Participants

Reaction Steps

To a solution of ethyl N-benzyl-glycinate (47.5 g, 0.268 mol) and N-carbobenzyloxy-L-alanine (60.0 g, 0.268 mol) in 600 ml of methylene chloride at 0° C. was added dropwise a solution of N,N'-dicyclohexylcarbodiimide (55.2 g, 0.268 mol) in 600 ml methylene chloride over a 1 hour period. After the addition was complete the solution was stirred for 10 min., warmed to room temperature and continued stirring overnight. The solution was filtered, washed with dilute aqueous HCl, H2O, saturated NaHCO3, brine, dried (MgSO4). Concentration of the solution in vacuo yielded the oily product.

Provenance & Evidence