Malic Acid → 1,4-Bis[2-(3-hydroxypropylamino)ethylamino)-5,8-dihydroxyanthraquinone dimalate salt

HRID 620291Notes

Reaction equation

HRID 620291 reaction equation
[OH:1][CH2:2][CH2:3][CH2:4][NH:5][CH2:6][CH2:7][NH:8][C:9]1[C:22]2[C:21](=[O:23])[C:20]3[C:15](=[C:16]([OH:25])[CH:17]=[CH:18][C:19]=3[OH:24])[C:14](=[O:26])[C:13]=2[C:12]([NH:27][CH2:28][CH2:29][NH:30][CH2:31][CH2:32][CH2:33][OH:34])=[CH:11][CH:10]=1.[C:35]([OH:43])(=[O:42])[CH:36]([CH2:38][C:39]([OH:41])=[O:40])[OH:37]>C(O)C>[C:35]([OH:43])(=[O:42])[CH:36]([CH2:38][C:39]([OH:41])=[O:40])[OH:37].[C:35]([OH:43])(=[O:42])[CH:36]([CH2:38][C:39]([OH:41])=[O:40])[OH:37].[OH:1][CH2:2][CH2:3][CH2:4][NH:5][CH2:6][CH2:7][NH:8][C:9]1[C:22]2[C:21](=[O:23])[C:20]3[C:15](=[C:16]([OH:25])[CH:17]=[CH:18][C:19]=3[OH:24])[C:14](=[O:26])[C:13]=2[C:12]([NH:27][CH2:28][CH2:29][NH:30][CH2:31][CH2:32][CH2:33][OH:34])=[CH:11][CH:10]=1

Participants

4

Reactant 2

HCID 525Malic AcidHCID 1531601,4-Bis[2-(3-hydroxypropylamino)ethylamino]-5,8-dihydroxyanthraquinone

Product 1

HCID 1317117371,4-Bis[2-(3-hydroxypropylamino)ethylamino)-5,8-dihydroxyanthraquinone dimalate salt

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 228 mg. of 1,4-bis[2-(3-hydroxypropylamino)ethylamino]-5,8-dihydroxyanthraquinone, 134 mg. of DL-malic acid and 50 ml. of ethanol is heated under reflux for 30 minutes to give the title compound.

Workup

  1. additionA mixture of 228 mg
  2. temperatureunder reflux for 30 minutes

Sources & evidence

ORD record
ord-52d5b4173aac4375bb4dfb0aec800439
Source dataset
uspto-grants-1989_04
Patent number
US04820738

Reaction notes

Loading…