Acetic Acid → 1,4-Bis[2-(3-hydroxypropylamino)ethylamino]-5,8-dihydroxyanthraquinone diacetate salt

HRID 620293Notes

Reaction equation

HRID 620293 reaction equation
[OH:1][CH2:2][CH2:3][CH2:4][NH:5][CH2:6][CH2:7][NH:8][C:9]1[C:22]2[C:21](=[O:23])[C:20]3[C:15](=[C:16]([OH:25])[CH:17]=[CH:18][C:19]=3[OH:24])[C:14](=[O:26])[C:13]=2[C:12]([NH:27][CH2:28][CH2:29][NH:30][CH2:31][CH2:32][CH2:33][OH:34])=[CH:11][CH:10]=1.[C:35]([OH:38])(=[O:37])[CH3:36]>C(O)C>[C:35]([OH:38])(=[O:37])[CH3:36].[C:35]([OH:38])(=[O:37])[CH3:36].[OH:1][CH2:2][CH2:3][CH2:4][NH:5][CH2:6][CH2:7][NH:8][C:9]1[C:22]2[C:21](=[O:23])[C:20]3[C:15](=[C:16]([OH:25])[CH:17]=[CH:18][C:19]=3[OH:24])[C:14](=[O:26])[C:13]=2[C:12]([NH:27][CH2:28][CH2:29][NH:30][CH2:31][CH2:32][CH2:33][OH:34])=[CH:11][CH:10]=1

Participants

4

Reactant 2

HCID 176Acetic AcidHCID 1531601,4-Bis[2-(3-hydroxypropylamino)ethylamino]-5,8-dihydroxyanthraquinone

Product 1

HCID 867369161,4-Bis[2-(3-hydroxypropylamino)ethylamino]-5,8-dihydroxyanthraquinone diacetate salt

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 228 mg. of 1,4-bis[2-(3-hydroxypropylamino)ethylamino]-5,8-dihydroxyanthraquinone, 60 mg. of glacial acetic acid, and 50 ml. of ethanol is heated under reflux for 30 minutes to give the title compound.

Workup

  1. additionA mixture of 228 mg
  2. temperatureunder reflux for 30 minutes

Sources & evidence

ORD record
ord-e38ac050905b46f4998aa3ca155db01b
Source dataset
uspto-grants-1989_04
Patent number
US04820738

Reaction notes

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