Aluminium lithium hydride → HCID 54216347, compound

Participants

Reaction Steps

A solution of 1.9 g (6.7 mmol) of rac-(1R*)-trans-2-[(R*)-4-chloro-α-(nitromethyl)benzyl]cyclohexanol in 30 ml of dry tetrahydrofuran is added dropwise while stirring to a suspension of 1 g of lithium aluminium hydride in 60 ml of dry tetrahydrofuran under argon, whereupon the mixture is stirred at 50° overnight. After cooling the reaction mixture is treated with tetrahydrofuran/water (1:1), the precipitate is filtered off under suction, the filtrate is evaporated, the residue is treated with water and extracted with ether. The rac-(1R*)-trans-2-[(R*)-α-(aminomethyl)-4-chlorobenzyl]cyclohexanol obtained is a colourless oil and is processed directly.

Provenance & Evidence