Tetrahydrofuran → HCID 15614938, compound

Participants

Reaction Steps

According to the procedure of O. Mitsunobu et al, Bull. Chem. Soc., Japan, 45, 3607 (1972), a solution of 2-bromo-6-methoxy-5-trifluoromethyl-1-naphthoic acid (4.50 g, 12.9 mmol, prepared by the process of Step 2, Example (11), and ethoxycarbonyl-t-butylcarbodiimide (2.40 g, 14.1 mmol) in dry tetrahydrofuran (80 mL) was heated to reflux under a dry nitrogen atmosphere for 21/3 hours. The THF was removed and the residue was dissolved in chloroform and the solvent evaporated. The resultant solid was triturated with ether (2×5 mL) and dried in vacuo to provide the title compound as an off white solid (4.61 g, 85%), m.p. 169°-171° C.

Provenance & Evidence