Hydrochloric Acid → HCID 21246146, compound

Participants

Reaction Steps

5-Methyl-6-[2-(3-t-butylamino-2-hydroxypropoxy)phenyl]-4,5-dihydro-3[2H]-pyridazinone (preparable from British Patent Specification No. 1488330) (1.3 g) and sodium 3-nitrobenzene sulphonate (0.88 g) were mixed in aqueous sodium hydroxide (0.38 g in 50 ml) and stirred under reflux for 3 hours. The reaction mixture was cooled, neutralised with hydrochloric acid and evaporated under reduced pressure to afford a residue. This was dissolved in water, on standing a solid precipitated which was filtered off (recovered sodium 3-nitrobenzene sulphonate). The filtrate was shaken with chloroform whereupon a white solid precipitated which was collected and dried to afford the title compound (0.4 g).

Provenance & Evidence