HuagongsheHuagongshe Chemistry Print Report · For research reference only
7-Aminodeacetoxycephalosporanic acid → HCID 88628807, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 7-Aminodeacetoxycephalosporanic acid | HCID 33498 | — |
| Reactant | Phenoxyacetyl chloride | HCID 69703 | — |
| Reactant | 7-Aminocephalosporanic acid | HCID 441328 | — |
| Reactant | HCID 88599689 | HCID 88599689 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | HCID 88628807 | HCID 88628807 | — |
Reaction Steps
The N-acylations are carried out by using the methods employed for the acylation of the cephalosporin nuclei such as 7-ACA and 7-ADCA. In an example of the acylation benzyl 7-amino-3-trifluoromethylsulfonyloxy-1-carba-3-cephem-4-carboxylate in acetonitrile is treated with phenoxyacetyl chloride in the presence of an acid-binding agent such as triethylamine or pyridine to provide benzyl 7-phenoxyacetylamino-3-trifluoromethylsulfonyloxy-1-carba-3-cephem-4-carboxylate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04820816 |
| Source dataset | uspto-grants-1989_04 |
| ORD ID | ord-2d60255d97a2459a831a56d8e633f6e0 |
| Source note | uspto-grants-1989_04 |