Acetic Anhydride → HCID 21246481, compound

HRID 620387Notes

Reaction equation

HRID 620387 reaction equation
[ClH:1].[NH:2]=[C:3]1[CH:8]=[CH:7][N:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[N:5]=[CH:4]1.[C:15](OC(=O)C)(=[O:17])[CH3:16]>>[ClH:1].[C:15]([N:2]=[C:3]1[CH:8]=[CH:7][N:6]([C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=2)[N:5]=[CH:4]1)(=[O:17])[CH3:16]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 21246174HCID 21246174, compound

Product 1

HCID 21246481HCID 21246481, compoundYield 74%

Procedure

15.0 g (72.2 millimoles) of 1,4-dihydro-4-imino-1-phenylpyridazine hydrochloride in 100 ml of acetic anhydride were heated at 100° C. for 2 hours, while stirring. The mixture was cooled and then filtered under suction, and the residue was washed with acetone and recrystallized from ethanol. 13.3 g (74% of theory) of 4-acetylimino-1,4-dihydro-1-phenylpyridazine hydrochloride were isolated as colorless crystals of melting point 257°-260° C.

Workup

  1. temperatureThe mixture was cooled
  2. filtrationfiltered under suction
  3. washthe residue was washed with acetone
  4. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-93987d29b1b94bf0a9dbc005056963a1
Source dataset
uspto-grants-1989_04
Patent number
US04820821

Reaction notes

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