Propionyl chloride → HCID 21246171, compound

HRID 620388Notes

Reaction equation

HRID 620388 reaction equation
Cl.[NH:2]=[C:3]1[CH:8]=[CH:7][N:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[N:5]=[CH:4]1.[C:15]([Cl:19])(=[O:18])[CH2:16][CH3:17]>>[ClH:19].[C:9]1([N:6]2[CH:7]=[CH:8][C:3](=[N:2][C:15](=[O:18])[CH2:16][CH3:17])[CH:4]=[N:5]2)[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1

Participants

3

Reactant 2

HCID 62324Propionyl chlorideHCID 21246174HCID 21246174, compound

Product 1

HCID 21246171HCID 21246171, compoundYield 41%

Procedure

5.0 g (24.1 millimoles) of 1,4-dihydro-4-imino-1-phenylpyridazine hydrochloride in 50 ml of propionyl chloride were refluxed for 20 hours, while stirring. The mixture was cooled and then filtered under suction, and the residue was recrystallized from ethanol/methyl tert.-butyl ether. 2.6 g (41% of theory) of 1,4-dihydro-1-phenyl-4-(propionylimino)-pyridazine hydrochloride were isolated as slightly yellowish crystals of melting point 214°-215° C.

Workup

  1. temperatureThe mixture was cooled
  2. filtrationfiltered under suction
  3. customthe residue was recrystallized from ethanol/methyl tert.-butyl ether

Sources & evidence

ORD record
ord-13f8a97a78c94e3bb0de72019b1fc97e
Source dataset
uspto-grants-1989_04
Patent number
US04820821

Reaction notes

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