Butyryl chloride → HCID 21246399, compound

HRID 620389Notes

Reaction equation

HRID 620389 reaction equation
Cl.[NH:2]=[C:3]1[CH:8]=[CH:7][N:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[N:5]=[CH:4]1.[C:15]([Cl:20])(=[O:19])[CH2:16][CH2:17][CH3:18]>>[ClH:20].[C:15]([N:2]=[C:3]1[CH:8]=[CH:7][N:6]([C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=2)[N:5]=[CH:4]1)(=[O:19])[CH2:16][CH2:17][CH3:18]

Participants

3

Reactant 2

HCID 8855Butyryl chlorideHCID 21246174HCID 21246174, compound

Product 1

HCID 21246399HCID 21246399, compoundYield 72%

Procedure

5.0 g (24.1 millimoles) of 1,4-dihydro-4-imino-1-phenylpyridazine hydrochloride in 50 ml of butyryl chloride were refluxed for 15 hours, while stirring. The mixture was cooled and then filtered under suction, and the residue was washed with acetone and recrystallized from isopropanol. 4.8 g (72% of theory) of 4-butyrylimino-1,4-dihydro-1-phenylpyridazine hydrochloride were isolated as pale beige crystals of melting point 205°-208° C.

Workup

  1. temperatureThe mixture was cooled
  2. filtrationfiltered under suction
  3. washthe residue was washed with acetone
  4. customrecrystallized from isopropanol

Sources & evidence

ORD record
ord-4d190590abb0409fae0daffa7135bc29
Source dataset
uspto-grants-1989_04
Patent number
US04820821

Reaction notes

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