Valeryl chloride → HCID 21246379, compound

HRID 620392Notes

Reaction equation

HRID 620392 reaction equation
Cl.[NH:2]=[C:3]1[CH:8]=[CH:7][N:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[N:5]=[CH:4]1.[C:15]([Cl:21])(=[O:20])[CH2:16][CH2:17][CH2:18][CH3:19]>>[ClH:21].[C:9]1([N:6]2[CH:7]=[CH:8][C:3](=[N:2][C:15](=[O:20])[CH2:16][CH2:17][CH2:18][CH3:19])[CH:4]=[N:5]2)[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1

Participants

3

Reactant 2

HCID 61186Valeryl chlorideHCID 21246174HCID 21246174, compound

Product 1

HCID 21246379HCID 21246379, compoundYield 40%

Procedure

6.0 g (28.9 millimoles) of 1,4-dihydro-4-imino-1-phenylpyridazine hydrochloride in 40 ml of valeryl chloride were kept at 120° C. for 20 hours, while stirring. The mixture was cooled and then filtered under suction, and the residue was washed with acetone and recrystallized first from ethanol/methyl tert.-butyl ether and then from ethanol/acetone. 3.4 g (40% of theory) of 1,4-dihydro-1-phenyl-4-(valerylimino)-pyridazine hydrochloride were isolated as pale yellowish crystals of melting point 180°-182° C.

Workup

  1. temperatureThe mixture was cooled
  2. filtrationfiltered under suction
  3. washthe residue was washed with acetone
  4. customrecrystallized first from ethanol/methyl tert.-butyl ether

Sources & evidence

ORD record
ord-4defbb777486401eafeb0b252b83ab6e
Source dataset
uspto-grants-1989_04
Patent number
US04820821

Reaction notes

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