2-Amino-2',5-dichlorobenzophenone → (2-Amino-3-bromo-5-chlorophenyl)(2-chlorophenyl)methanone

Participants

Reaction Steps

A 20 g sample of (2-amino-5-chlorophenyl)(2-chlorophenyl)methanone, (the compound of formula II) a compound which can be prepared according to known methods, was dissolved in 100 mL of acetic acid and 4 mL of bromine was added. The mixture was heated at reflux for two hours, cooled and concentrated in vacuo to a residue which was crystallized from ethanol yielding (2-amino-3-bromo-5-chlorophenyl)(2-chlorophenyl)-methanone having a m.p. of 100°-101° C.

Provenance & Evidence