HCID 19423821, compound → HCID 70045402, compound

HRID 620411Notes

Reaction equation

HRID 620411 reaction equation
O.[N:2]1([C:13](=[O:14])[C:12]2[N:11]([CH2:15][C:16]([O-:18])=[O:17])[CH:10]=[N:9][C:8]=2[N:6]([CH3:7])[C:4]1=[O:5])[CH3:3].[CH2:19]([O:21][C:22]1[CH:23]=[C:24]([CH:42]=[CH:43][C:44]=1[O:45][CH2:46][CH3:47])[CH2:25][C:26]1[C:35]2[C:30](=[CH:31][C:32]([O:39][CH2:40][CH3:41])=[C:33]([O:36][CH2:37][CH3:38])[CH:34]=2)[CH2:29][CH2:28][NH+:27]=1)[CH3:20]>CC(C)=O>[CH2:19]([O:21][C:22]1[CH:23]=[C:24]([CH:42]=[CH:43][C:44]=1[O:45][CH2:46][CH3:47])[CH2:25][C:26]1[C:35]2[C:30](=[CH:31][C:32]([O:39][CH2:40][CH3:41])=[C:33]([O:36][CH2:37][CH3:38])[CH:34]=2)[CH2:29][CH2:28][NH+:27]=1)[CH3:20].[N:2]1([C:13](=[O:14])[C:12]2[N:11]([CH2:15][C:16]([O-:18])=[O:17])[CH:10]=[N:9][C:8]=2[N:6]([CH3:7])[C:4]1=[O:5])[CH3:3]

Participants

3

Reactant 1

HCID 19423821HCID 19423821, compound

Product 1

HCID 70045402HCID 70045402, compoundYield 96.7%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Into a 250 ml four-necked flask equipped with a stirrer 25 g of 1-(3',4'-diethoxy-benzyl)6,7-diethoxy-3,4-dihydro-isoquinolinium-theophylline-7-acetate-monohydrate and 250 ml of anhydrous acetone are weighed in. The reaction mixture is stirred at room temperature for 5 hours. The crystalline product is transformed into a loose yellowish-white thick substance, which is filtered, washed twice with 20 ml of acetone each and dried. Thus 23.5 g of the desired compound are obtained, yield 96.5%. mp: 152°-154° C. The product is identical with the substance prepared according to Example 4.

Workup

  1. filtrationis filtered
  2. washwashed twice with 20 ml of acetone each and
  3. customdried

Sources & evidence

ORD record
ord-c90c9ccd64a44f77ad9734e38acead16
Source dataset
uspto-grants-1989_04
Patent number
US04820838

Reaction notes

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