HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 62047Generated: October 27, 2026
4-Fluorophenyl isocyanate → 1-(4-fluorophenyl)-3-(4-(1-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazol-3-yl)phenyl)urea
https://huagongshe.com/reaction/62047
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Fluorophenyl isocyanate | HCID 70955 | — |
| Reactant | 4-(1-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazol-3-yl)aniline | HCID 57824490 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-(4-fluorophenyl)-3-(4-(1-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazol-3-yl)phenyl)urea | HCID 118675188 | 49.1% |
Reaction Steps
To 4-(1-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazol-3-yl)aniline (0.200 g, 0.624 mmol) and 1-fluoro-4-isocyanatobenzene (0.257 g, 1.87 mmol) in a 25 mL round-bottomed flask was added tetrahydrofuran (10 mL). The solution was heated to 65° C. for 2 hours before the solvent was removed under reduced pressure. Purification by flash column chromatography provided the title compound (0.140 g, 49%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09445594B2 |
|---|
| Source dataset | uspto-grants-2016_09 |
|---|
| ORD ID | ord-c2a4e8b722e24e459dc9dfc5cf75c201 |
|---|
| Source note | uspto-grants-2016_09 |
|---|
