HuagongsheHuagongshe Chemistry Print Report · For research reference only
4,4-Dimethyl-2-(2-methoxyphenyl)oxazoline → 2-[2-(12,12,12-Trifluorododecyl)phenyl]-4,4-dimethyloxazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4,4-Dimethyl-2-(2-methoxyphenyl)oxazoline | HCID 333189 | — |
| Reactant | Ethyl 5-(2-Dodecylphenyl)-E-4-pentenoate | HCID 15617433 | — |
| Reactant | 3-(2-Carboxyethylthio)-3-[2-(6-phenylhexyloxy)phenyl]propanoic acid | HCID 19817980 | — |
| Reactant | HCID 178506315 | HCID 178506315 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-[2-(12,12,12-Trifluorododecyl)phenyl]-4,4-dimethyloxazoline | HCID 19817978 | — |
Reaction Steps
Following the procedures of Example 1(a), (b) and (c), 12,12,12-trifluorododecylmagnesium bromide (from 29.19 mmoles of 12,12,12-trifluorododecyl bromide and 25.71 mmoles of magnesium) was reacted with 2-(2-methoxyphenyl)-4,4-dimethyloxazoline (20.17 mmoles) in tetrahydrofuran to give 2-[2-(12,12,12-trifluorododecyl)phenyl]-4,4-dimethyloxazoline. The oxazoline (14.39 mmoles) was converted to the methiodide salt and then reduced with sodium borohydride (13.43 mmoles) to yield the desired product as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04820719 |
| Source dataset | uspto-grants-1989_04 |
| ORD ID | ord-ff3d3c7ba7d0434f94b0b3659b4f6cc0 |
| Source note | uspto-grants-1989_04 |