反应详情

温度

70 °C

To a 20 mL vial, 2-(4-(1-(4-(perfluoroethoxy)phenyl)-1H-1,2,4-triazol-3-yl)phenyl)acetyl azide (0.100 g, 0.228 mmol) was suspended in acetonitrile (1.5 mL). The suspension was stirred in a pre-heated heating block at 70° C. for 2 hours. The suspension was cooled to room temperature, then 2-isopropylaniline (0.0339 g, 0.251 mmol) and cesium carbonate (0.0890 g, 0.274 mmol) were added. The reaction was allowed to stir for overnight at room temperature. The reaction was filtered through a fritted funnel. The filtrate was concentrated onto Celite® and purified by reverse phase chromatography using 5-100% acetonitrile/water as eluent to provide the title compound as a white solid (0.028 g, 22%).

1. temperatureThe suspension was cooled to room temperature
2. stirringto stir for overnight at room temperature
3. filtrationThe reaction was filtered through a fritted funnel
4. concentrationThe filtrate was concentrated onto Celite®
5. custompurified by reverse phase chromatography