Triethylamine → 1-(2-isopropylphenyl)-3-(3-(4-(1-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazol-3-yl)phenyl)propyl)thiourea

Participants

Reaction Steps

In a 25 mL flask, to a solution of 3-(4-(1-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazol-3-yl)phenyl)propan-1-amine (0.160 g, 0.442 mmol) in dichloromethane (2 mL) was added 1-isopropyl-2-isothiocyanatobenzene (0.156 g, 0.530 mmol) in dichloromethane (5 mL) followed by triethylamine (0.062 mL, 0.442 mmol). The reaction mixture was stirred overnight at room temperature. The reaction mixture was diluted with ethyl acetate and adsorbed onto Celite®. Purification by flash column chromatography provided the title compound as a white solid (110 mg, 49%).

Provenance & Evidence