HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Cyanobenzoyl chloride → 4-Cyano-N-(2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl)-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Cyanobenzoyl chloride | HCID 80172 | — |
| Reactant | 3-Amino-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one | HCID 4259649 | — |
| Product | 4-Cyano-N-(2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl)-benzamide | HCID 14208267 | — |
Reaction Steps
The procedure of Example 134 was carried out employing equivalent amounts of 1,3-dihydro-3-(RS)-amino-5-phenyl-2H-1,4-benzodiazepin-2-one and 4-cyanobenzoylchloride. The product was purified by chromatography on silica gel (5% (v/v) Et2O in CH2Cl2 elution). The combined product fractions were evaporated to dryness in vacuo and crystallized to give the title compound which was dried at 65° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04820834 |
| Source dataset | uspto-grants-1989_04 |
| ORD ID | ord-9ac063e59f444b819d615fc323519d1f |
| Source note | uspto-grants-1989_04 |