(3RS)-3-amino-1-ethoxycarbonylmethyl-5-(2-fluorophenyl)-2,3-dihydro-1H-1,4-benzodiazepin-2-one → 5-(2-Fluorophenyl)-2,5-dihydro-3-((((1-methylethyl) amino)carbonyl)amino)-2-oxo-1H-1,4-benzodiazepine-1-acetic acid ethyl ester

Participants

Reaction Steps

Equimolar amounts of 3(R,S)-amino-1,3-dihydro-1-ethoxycarbonylmethyl-5-(2-fluorophenyl)-2H-1,4-benzodiazepin-2-one and isoproplylisocyanate were mixed in 8 ml of dry tetrahydrofuran at room temperature. The reaction mixture was allowed to stand for 8 hours and was then filtered. The collected solids were washed with tetrahydrofuran and dried in vacuo over P2O5 to give the analytical product: m.p. 155°-157° C.

Provenance & Evidence